منابع مشابه
Guanidine block of single channel currents activated by acetylcholine
The acetylcholine-activated channel of chick myotube was studied using the patch-clamp method. Single channel current amplitudes were measured between -300 and +250 mV in solutions containing the permeant ions Cs+ and guanidine (G+). G+ has a relative permeability, PG/PCs, of 1.6, but carries no more than half the current that Cs+ does, with an equivalent electrochemical driving force. Experime...
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Qeshm Channel is a shallow and narrow waterway located between Qeshm Island and the mainland in the vicinity of Hormuzgan Province, Islamic Republic of Iran. This channel is important because of its economic, industrial, fisheries and navigation role it plays as well as environmental issues it presents in the region. A prognostic study was performed to simulate currents in this channel, using C...
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Kv1.5 is considered to be a potential molecular target for treatment of atrial fibrillation or flutter. Disopyramide is widely used in the treatment of atrial flutter and/or atrial fibrillation. The present study was undertaken to characterize the effects of disopyramide on currents mediated by Kv1.5 channels and to determine the putative binding site involved in the inhibitory effects of disop...
متن کاملSodium channel slow inactivation interferes with open channel block
Mutations in the voltage-gated sodium channel Nav1.7 are linked to inherited pain syndromes such as erythromelalgia (IEM) and paroxysmal extreme pain disorder (PEPD). PEPD mutations impair Nav1.7 fast inactivation and increase persistent currents. PEPD mutations also increase resurgent currents, which involve the voltage-dependent release of an open channel blocker. In contrast, IEM mutations, ...
متن کاملMechanism of secondary currents in open channel flows
This paper describes the conditions for initiation and maintenance of secondary currents in open channel flows. By analyzing the Reynolds equation in the wall-normal and wall-tangent directions, this study reveals that, like other types of vortices, the secondary currents are originated in the near-boundary region, and the magnitude (or strength) of secondary flow is proportional to the lateral...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2008
ISSN: 1347-8613,1347-8648
DOI: 10.1254/jphs.fp0070759